The design of the S1Pro ensures that it turns heads. At a time when most brands have been following a template of sorts when it comes to multiple camera arrangements on the back, the S1Pro combines a beautifully crafted and gently curving gradient finished back with a diamond AI Quad Rear Camera arrangement. Yes, the four cameras on the back are placed in a unit that is shaped like a diamond, with a coloured line connecting the camera in the middle with one of the corners. There is no way you can confuse this phone with any other. At 8.68 mm thin, it is super slim, and its 186 grams weight gives it a very reassuring heft. Whether you go for the Mystic Black, the Jazzy Blue or the Dreamy White variant, the S1Pro delivers a loud and clear style statement.
Vivo Upgrades the Style Statement with Vivo S1 Pro in Pakistan
vivo, the global innovative smartphone brand has unveiled its new S1 Pro in Pakistan at special media launch event, held in Lahore. Media, Technology and Fashion enthusiasts witnessed the launch of this new smartphone featuring a unique Diamond Design with 48MP AI Quad Camera, 32MP Front Camera, In-Display Fingerprint Scanning, 4500mAh Battery with vivo's Dual-Engine Fast Charging.
Commenting on the launch Mr. Zohair Chohan, vivo's Brand Manager in Pakistan said "vivo continues its journey of innovation in Pakistan with the new S1 Pro, a smartphone that upgrades your style with its unique design and an impressive set of features. With its ground-breaking innovations anchored on future technologies and trend-setting design that offers the best smartphone experience, vivo will continue adding significant value to the lives of our consumers in the year 2020."
The reason for PPI responsiveness of this condition is not completely understood but could be due to other, non-antisecretory effects of PPIs [118], of which the anti-inflammatory action [119] is the most relevant one. In vitro and in vivo studies suggest that the anti-inflammatory effects of PPI therapy rather than acid suppression alone may be responsible for this improvement through inhibition of the Th2-allergic pathway [120]. Indeed, like topical corticosteroids, PPIs down-regulated cytokine expression [121]. Alternatively, the dilated intercellular spaces and consequent increased mucosal permeability, present in EoE [122], may allow allergen penetration, which triggers subsequent recruitment of eosinophils to the esophageal epithelium. Some studies have shown that dilated intercellular spaces could recover after short-term PPI treatment in GERD (for review see [123]), a finding recently reported in patients with PPI-REE [124].
An effective therapy should be able to eradicate the organism from each of these potential niches, which is an overwhelming task for any single antibiotic, whose in vitro susceptibility does not necessarily correlate with successful treatment in vivo. Since the very beginning, it was recognized that therapy with a single antibiotic leads to poor cure rates and various recipes were attempted, resulting in several effective combinations of antimicrobials, bismuth, and antisecretory drugs [136].
The inhibitory activity on H. pylori urease has been confirmed in vivo. As a consequence, PPI administration results in the inability to detect the microorganism, thus interfering with the urease-based diagnostic tests [90, 145]. The temporary inability to detect the presence of H. pylori is termed suppression and simply reflects a decrease in the number of bacteria below the limits of detection [145]. It is worth mentioning that the infection affects the degree and the duration of acid inhibition achieved by antisecretory drugs. Amongst the mechanisms by which the microorganism could modify the pH-rising effect of PPIs, the buffering of H. pylori-generated ammonia on gastric acid remains the most convincing one [69].
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